Yes, I think I have that env enabled. Other games work with S3TC. I believe libtxc_dxtn for 32-bit is not installed on my system, only the 64bit version. It may also be that the 32bit emulation libs/drivers provided by the distribution have no S3TC support built-in. Is it already possible to compile a 64bit TDM? X - GL_EXT_texture_compression_s3tc not found Relevant parts of glxinfo: GL_EXT_texture_compression_rgtc, GL_EXT_texture_compression_s3tc, GL_OES_read_format, GL_S3_s3tc GL_EXT_texture_compression_s3tc, GL_EXT_texture_cube_map, GL_OES_read_format, GL_S3_s3tc, GL_S